The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity.

Chen Zhang,Pernille Barkholt,Jens Christian Nielsen,Ditte Dencker Thorbek,Kristoffer Rigbolt,Niels Vrang,David Paul Drucker Woldbye,Jacob Jelsing

Brain Research（2020）

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摘要

•Unbiased transcriptome analysis of 6 brain nuclei in lean and obese rats.•88 genes were differentially expressed between lean and obese.•Dorsomedial hypothalamus and nucleus of the solitary tract are the key nuclei.•Neuropeptides and regulation of signaling pathways are the top enriched GO terms.

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关键词

Obesity,Laser capture microdissection,RNAseq,Transcriptome,Neuropeptide

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