Structural, functional, and molecular impact on the cardiovascular system in ApoE -/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

Justyna Szostak,Bjoern Titz,Walter K Schlage,Emmanuel Guedj,Alain Sewer,Blaine Phillips,Patrice Leroy,Ansgar Buettner,Laurent Neau,Keyur Trivedi,Florian Martin,Nikolai V Ivanov,Patrick Vanscheeuwijck,Manuel C Peitsch,Julia Hoeng

Chemico-Biological Interactions（2020）

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摘要

•cMRTP aerosols induce less atherosclerotic plaque formation than CS.•cMRTP aerosols induce lower molecular changes in the aorta and heart tissues than CS.•Smoking cessation reverses gene expression changes in the heart ventricle and aorta.

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关键词

Ahr,ApoE-/- mice,Atherosclerosis,Cigarette smoke,Candidate modified-risk tobacco products,Heart ventricle dysfunction,Xenobiotic metabolism

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