GM1 Ganglioside role in the interaction of Alpha-synuclein with lipid membranes: Morphology and structure.

F Perissinotto,V Rondelli,P Parisse, N Tormena,A Zunino,L Almásy,D G Merkel,L Bottyán,Sz Sajti,L Casalis

Biophysical Chemistry（2019）

引用 38|浏览12

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摘要

•Monomeric AS remodels membrane structure leading to bilayer thinning in both phospholipid and phospholipid/GM1 membranes.•Iron-mediated AS oligomers show an increased tendency in membrane binding.•GM1 acts as a membrane-binding mediator for alpha-synuclein.

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关键词

Alphasynuclein,Model membrane,GM1,Neutron scattering,Neutron reflectometry,AFM

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