Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model.

Robert B Klanderman,Joachim J Bosboom,Adrie A W Maas,Joris J T H Roelofs,Dirk de Korte,Robin van Bruggen,Jaap D van Buul,Coert J Zuurbier,Denise P Veelo,Markus W Hollmann,Margreeth B Vroom,Nicole P Juffermans,Bart F Geerts,Alexander P J Vlaar

Transfusion（2019）

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摘要

To our knowledge, this is the first animal model for TACO, showing that a combination of volume incompliance and transfusion is essential for development of circulatory overload. This model allows for further testing of mechanistic factors as well as therapeutic approaches.

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