P2X 7 receptor knockout mice display less aggressive biting behaviour correlating with increased brain activation in the piriform cortex.

Kristie Leigh Smith,Stephanie M Todd,Aurelie Boucher,Maxwell R Bennett,Jonathon C Arnold

Neuroscience Letters（2020）

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摘要

•P2rx7 in mice mediates obsessive-compulsive disorder-related and aggressive behavior.•P2rx7 deletion reduces marble burying in early adulthood compared to wild type mice.•P2rx7 deletion decreases aggressive biting behaviour compared to wild type mice.•Decreased aggression in P2rx7 KO mice coincides with increased piriform activation.

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关键词

P2X7,Obsessive compulsive disorder,Aggression,Piriform cortex,c-Fos,Microglia

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