HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis

Ranjan Ramasamy,Fiyaz Mohammed,Ute-C. Meier

Immunology Letters（2020）

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摘要

•Molecular basis for likely autoimmune origin of multiple sclerosis investigated.•Human endogenous retrovirus envelope and Epstein Barr virus proteins implicated.•Mimicry between brain and virus-derived proteins proposed.•HLA DR2b binding pairs of potential TH cell epitopes identified.•Modelling shows HLA DR2b binding similar to established TH cell epitope.

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关键词

ABP,βSYN,BLAST,CNS,EAE,EBV,EBNA1,env,HERV,IEDB,MAG,MBP,MOG,MS,MSRV,NCBI,OSP,PLP,SMM,SYN1,SYN2,TCR

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