CFTR processing, trafficking and interactions

Margarida D. Amaral,Darren M Hutt,Valeria Tomati,Hugo M. Botelho,Nicoletta Pedemonte

Journal of Cystic Fibrosis（2020）

引用 18|浏览54

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摘要

•CF mutations with similar phenotype can have different protein-interaction networks.•Specific protein networks impact CFTR synthesis, folding, trafficking and function.•Manipulation of interacting proteins can lead to new therapeutic opportunities.

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关键词

CFTR Cl-channel,F508del-CFTR,CFTR correctors,Proteostasis regulators,CFTR interactome,CFTR functional landscape,siRNA screening

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