DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile.

B C M Hermans,J L Derks,E Thunnissen,R J van Suylen,M A den Bakker,H J M Groen,E F Smit,R A Damhuis,E C van den Broek, A Ruland,E J M Speel,A M C Dingemans

Lung Cancer（2019）

引用 33|浏览51

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摘要

•DLL3 is expressed in 74% of stage IV LCNEC patients•The majority (80%) has cytoplasmic/membranous expression•DLL3 is expressed in both SCLC- and NSCLC-like LCNEC subtype•6/6 STK11mt, 10/11 KEAP1mt and 9/9 TP53wt tumors were DLL3 positive•DLL3 expression is associated with expression of ASCL1 and neuroendocrine markers

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关键词

Large cell neuroendocrine carcinoma (LCNEC),Lung cancer,DLL3,ASCL1,RB1

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