Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia.

Genta Ishikawa,Naoto Fujiwara,Hadassa Hirschfield,Lilian Varricchio,Yujin Hoshida,Giovanni Barosi,Vittorio Rosti,Maria Padilla,Maria Mazzarini,Scott L Friedman,Ronald Hoffman,Anna Rita Migliaccio

Experimental Hematology（2019）

引用 9|浏览48

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摘要

•Unlike liver and lung fibrosis and ET BM, BM from PMF expresses a signature of noncanonical TGF-β signaling activation.•This signature identifies TGF-β as potential target for micro-environment therapy in PMF.

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关键词

Bone Marrow,Fibrosis,Myeloproliferative Neoplasms,Primary Mielofibrosis,TGF-β

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