How presence of a signal peptide affects human galectins-1 and -4: Clues to explain common absence of a leader sequence among adhesion/growth-regulatory galectins.
Biochimica et Biophysica Acta (BBA) - General Subjects(2020)
摘要
•Galectins-1 and -4 maintain activity when misdirected to the ER-Golgi route.•Galectins-1 and -4 become N-glycosylated at ER entry.•Misdirected galectins-1 and -4 differ in localization and secretion.•N-Glycosylation of galectins may disturb interactions and lattice formation.
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关键词
Glycosylation,Golgi,Lectin,Secretion,Signal peptide,Signal sequence
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