Outcomes of Macrolide Deescalation in Severe Community-Acquired Pneumonia.

Tiffany M Hopkins,Paul Juang, Katherine Weaver,Marin H Kollef,Kevin D Betthauser

Clinical Therapeutics（2019）

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摘要

In this study of ICU patients with severe CAP and a negative BioFire PCR result, deescalation from combination β-lactam and macrolide therapy to β-lactam monotherapy was not associated with increased in-hospital mortality but was associated with decreased hospital and ICU LOS. Larger prospective studies are warranted to verify these findings.

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antimicrobial stewardship,antimicrobial therapy,community-acquired pneumonia,intensive care unit

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