N2 neutrophils may participate in spontaneous recovery after transient cerebral ischemia by inhibiting ischemic neuron injury in rats

Ying Hou,Depeng Yang,Rongwu Xiang,Huiyang Wang,Xianshi Wang,Haotian Zhang,Pengwei Wang,Zhen Zhang,Xiaohang Che,Yinglu Liu,Yongfeng Gao,Xiangnan Yu,Xiaoyun Gao,Wen Zhang,Jingyu Yang,Chunfu Wu

International Immunopharmacology（2019）

引用 27|浏览15

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摘要

•N2 neutrophils ameliorate OGD/R-induced neuronal injury via BDNF/TrkB signaling.•The injury induced by tMCAO exhibit spontaneous recovery over time in rats.•The number of neutrophils in brain is positively correlated with BBB permeability.•The number of neutrophils in brain is positively correlated with CINCs levels.•N2 neutrophils is positively correlated with spontaneous recovery after tMCAO.

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关键词

N2 neutrophil,Primary cortical neuron,Oxygen glucose deprivation/re-oxygenation,BDNF/TrkB,Transient cerebral ischemia,Spontaneous recovery

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