Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization.

•We evaluated changes of blood steroidome in anorectic women during the refeeding.•GC–MS/MS analysis of 45 steroids followed by multivariate regression was completed.•Severity of anorexia correlated with 7β-/16α-hydroxylation of adrenal C19 steroids.•Severity of anorexia correlate with activities of further steroidogenic enzymes.•Catabolism of substrates for sex hormones correlated with severity of anorexia.