Perovskanol, a new sesquiterpenoid with an unprecedented skeleton from Perovskia Abrotanoides

Phytochemical investigation of the aerial parts of Perovskia abrotanoides (Lamiaceae) by normal phase column chromatography resulted in the isolation of perovskanol (1), a novel sesquiterpenoid possessing a 5/7/5 fused carbon ring skeleton. The structure of 1 was established by comprehensive spectroscopic data analysis including 1 D and 2 D NMR and HRESIMS. The antiprotozoal activity of compound 1 was evaluated against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, Plasmodium falciparum and no promising activities were shown against all parasite tested.