Inhibition of Ku70 in a high- glucose environment aggravates bupivacaine-induced dorsal root ganglion neurotoxicity.

Yongwei Wang,Luying Lai,Wenjing Guo,Shenghui Peng,Ruimeng Liu,Pu Hong,Guanshan Wei,Fengxian Li,Shan Jiang,Pei Wang,Ji Li,Hongyi Lei,Wei Zhao,Shiyuan Xu

Toxicology Letters（2020）

引用 5|浏览12

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摘要

•High glucose causes an increase in cell toxicity induced by BP.•High glucose aggravated BP-induced DNA damage and apoptosis.•High glucose aggravated BP-induced DNA damage through inhibit DNA-PK/Ku70 protein.

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关键词

DNA damage,DNA repair,Ku70,DRG,Neurotoxicity,Bupivacaine

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