An improved extraction protocol for therapeutic dabigatran monitoring using HPLC-MS/MS.

Alexey V Kozlov,Galina V Ramenskaya,Dmitry A Sychev,Alexander M Vlasov, Lyubov M Makarenkova,Elena S Stepanova,Vladimir I Gegechkori,Snezana Agatonovic-Kustrin, Victor V I Chistyakov

Journal of Chromatography B（2019）

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摘要

•A new sample extraction protocol for dabigatran in blood samples was developed.•Agilent Zorbax SB-CN column has improved sample resolution and avoided early elution of dabigatran.•HPLC-tandem MS/MS has been developed for pharmacokinetic studies of dabigatran.

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关键词

Dabigatran,Extraction protocol,HPLC-MS/MS,Anticoagulant,Pharmacokinetics

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