Antagonistic role of IL-1ß and NLRP3/IL-18 genetics in chronic HIV-1 infection.

Edione C Reis,Vinicius N C Leal,Lais T da Silva, Marilia M L Dos Reis,Enrique R Argañaraz,Telma M Oshiro,Alessandra Pontillo

Clinical Immunology（2019）

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摘要

Host genetics affects both susceptibility and progression of HIV-1 infection. NLRP3 inflammasome provides a first-line defense in viral infections, and, accordingly, gain-of-function variants in NLRP3 have been associated with protection against HIV-1.

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关键词

HIV-1, chronic infection,NLRP3,Inflammasome,IL-1ß,IL-18

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