KRas G12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals.

Cindy L Hochstetler,Yuxin Feng,Mehmet Sacma,Ashley K Davis,Mahil Rao,Chia-Yi Kuan,Li-Ru You,Hartmut Geiger,Yi Zheng

Experimental Hematology（2019）

引用 7|浏览7

暂无评分

摘要

•Endothelial KRasG12D expression affects normal hematopoiesis with a myeloid bias.•Endothelial KRasG12D causes reduced HSC function in a competitive transplant setting.•KRasG12D in endothelial cells elicits an inflammatory signal in the bone marrow niche.

查看译文

关键词

Endothelial Cells,HSPCs,KRas(G12D)

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要