The Construction and Characterization of Mirror-imaged L-DNA i-Motif.

Yawei Sun,Bo Yang,Yi Hua,Yuanchen Dong,Jianhan Ye,Jiqian Wang,Lijin Xu,Dongsheng Liu

CHEMBIOCHEM（2020）

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摘要

The first thermally stable and pH-responsive quadruplex intercalated motif (i-motif) structure formed by l-DNA is presented. Although this l-type i-motif exhibits the same physiochemical properties as its d isomer, its inverted chirality and good enzymatic resistance potentially open the way to the development of new DNA materials of pharmaceutical and biological interest.

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关键词

chirality,DNA structures,i-motifs,l-DNA,self-assembly

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