Implementation Of Bayesian Study Design In The Spyral Htn-Off Med Pivotal Trial

Michael Böhm,Raymond Townsend,Michael Weber,David Kandzari,Felix Mahfoud,Kazuomi Kario,Roland Schmieder,Konstantinos Tsioufis,Vanessa DeBruin,Graeme Hickey,Martin Fahy,Stuart Pocock

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2019）

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摘要

Implementation of an adaptive study design and leveraging historical data have the potential to significantly reduce the number of patients required for a clinical study. Herein we describe the adaptive study design used in the SPYRAL HTN-OFF MED Pivotal trial. The SPYRAL HTN-OFF MED Pivotal trial

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