Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy

•Glucocorticoid receptors (GRs) control brain cell functions at the neurovascular unit.•Glucocorticoid receptor dysfunction is associated with neuropathological conditions.•Glucocorticoid and drugs targeting neurological disorders operate through GR regulatory mechanisms.•Glucocorticoid resistance could further aggravate neurological conditions.