Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer

•This observational cohort study identifies dosimetric predictors of toxicity in patients with anal squamous cell carcinoma who were treated with curative intent image-guided intensity-modulated radiation therapy and concurrent chemotherapy.•This study helps to define relevant dosimetric parameters to consider in radiation treatment planning to reduce the risk of acute and late toxicity.•These dosimetric parameters facilitate individualized predictions of acute and late complication risk.