Abstract 10843: Mutated Desmoglein-2 Proteins in Arrhythmogenic Right Ventricular Cardiomyopathy are Incorporated into the Desmosome and Exhibit Dominant-negative Effects

Torsten B Rasmussen,Johan Palmfeldt,Peter H Nissen,Raffaela Magnoni,Søren Dalager,Uffe B Jensen,Won Y Kim,Lene Heickendorff, Henning Mølgaard,Henrik K Jensen,Ulrik T Baandrup,Peter Bross,Jens Mogensen

Circulation（2012）

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摘要

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary cardiac condition associated with ventricular arrhythmias, heart failure, and sudden death. The majority of ARVC p...

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