Collecting ducts carcinoma: An orphan disease. Literature overview and future perspectives

•Collecting ducts carcinoma (CDC) is a rare and aggressive disease.•Incurable when metastatic, chemotherapy has palliative role with poor responses.•Case reports with targeted therapy and encouraging results, scarce strong evidences.•Molecular characterize CDC to find recurrent alterations and potential targets.•New biological driven approaches, immune-checkpoint inhibitors are feasible.