IDDF2019-ABS-0225 lncRNA w01880 is downregulated in gastric cancer cell and inhibited proliferation and metastasis

Background Gastric cancer (GC) is one of the common cancers in China, and its pathogenesis is still unknown. Recent studies have reported that long non-coding RNAs (lncRNAs) are important regulators of GC. However, the role and mechanism of lncRNAs in GC are poorly understood. In this study, we characterized a novel lncRNA termed w01880 in GC tissues and cell lines. Methods We used reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to assayed w01880 levels in GC tissues and cell lines. Lentiviral vector was used to manipulate the expression of w01880 (IDDF2019-ABS-0225 Figure 1C). Biological functions of w01880 were analyzed using Cell Counting Kit-8 (CCK-8) and Wound Healing in vitro. Results We analyzed a cohort of 64 patients and found that w01880 was significantly down-expressed in GC tissues compared with paired adjacent normal tissues ((figure 1A), P Conclusions Our data suggested that w01880 functioned as a tumor suppressor lncRNA in GC, which provided a potential biomarker and therapeutic target for GC.