Performance of a 2D-SWE implemented on a new system for predicting different stages of liver fibrosis using Transient Elastography as the reference method

Aim To evaluate the performance of 2D Shear-Wave Elastography from General Electric (2D-SWE.GE), implemented on the new LOGIQ P9 system, for the non-invasive assessment of liver fibrosis, and to identify liver stiffness (LS) cut-off values for predicting different stages of fibrosis, using Transient Elastography (TE) as the reference method. Material and Method Our study included 234 consecutive subjects, with or without chronic hepatopathies, in whom LS was evaluated in the same session by means of two elastographic techniques: TE (FibroScan, EchoSens) and 2D-SWE.GE (LOGIQ P9, GE Healthcare). Reliable liver stiffness measurements (LSM) were defined for TE as the median value of 10 measurements with an interquartile range/median ratio (IQR/M) Results Reliable LS measurements were obtained in 217/234 (92.7%) subjects by 2D-SWE.GE and in 222/234 (94.8%) by TE, so the final analysis included 205 subjects (p = 0.454). 36% (74/205) of subjects included in the study were healthy liver subjects. Based on TE [1] cut-off values we divided the rest of our cohort into 4 groups: F Conclusion The mean LS values for normal subjects for 2D-SWE-GE (P9) was 5.05 ± 0.83 kPa. The best 2D-SWE.GE (P9) cut-off values for predicting F ≥ 2, F ≥ 3 and F = 4 were 6.8 kPa, 7.6 kPa and 9.3 kPa.