Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy

Paola Aiello,Sara Consalvi,Giovanna Poce,Anna Raguzzini,Elisabetta Toti,Maura Palmery,Mariangela Biava,Marco Bernardi,Mohammad A. Kamal,George Perry,Ilaria Peluso

Seminars in Cancer Biology（2021）

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摘要

Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activity of nanoparticles (NPs) obtained from food-derived flavonoids. From a systematic search a total of 60 studies were identified. Most of the studies involved the flavanol epigallocatechin-3-O-gallate and the flavonol quercetin, in both delivery and co-delivery (with anti-cancer drugs) systems. Moreover, some studies investigated the effects of other flavonoids, such as anthocyanins aglycones anthocyanidins, flavanones, flavones and isoflavonoids. NPs inhibited tumor growth in both xenograft and chemical-induced animal models of cancerogenesis.

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关键词

2-AAF,67LR,ALP,ALT,API,AST,ATC,AUC,BaP,BCL,BR,BSA,BW,CAT,CD44R,CH,CHOL,CIS,Cmax,CMS,COX-2,CS,CSU,CTX,Cy,DEN,DMBA,DOX,Dp,DSPE-MPEG,EAC,EGCG,EGFR,EIF5A2,ER,ERK,Eudragit,FA,FITC,FR,FU,GEN,GPNLC,GPSLN,GSH,GST,HA,Hb,HES,IC50,IFN,IL,IR,KpK,MDA,MDR,MNU,MPEG–PCL,MPEG-PLA,M-PLGA–TPGS,MPO,MPP,MSN,Mv,NF-κB,NPs,Nrf2,PAA,PBS,PC,PCL,PCNA,Pe,PE,PEG,PEG-DSPE,PEG-PCL,Pg,PLA,PLGA,PMSN,pPhe-pHis-PEG,PS,PSA,PSMA,Pt,PTX,PVA,QCT,ROS,SA,SCID,SNEDDS,SOD,SPC,Tf,TfR,Tmax,TMX,TNF,TPGS,TPP,TPs,TPT,UVB,VEGF

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