Pd-Catalyzed Atroposelective C–H Allylation and Alkenylation: Access to Enantioenriched Atropisomers Featuring Pentatomic Heteroaromatics

The development of efficient and unified synthetic methods to access enantioenriched pentatomic biaryls is extremely challenging, due to the relatively low rotational barriers of these five-membered atropisomeric species, Described herein is a Pd-catalyzed asymmetric C–H allylation and alkenylation to prepare such atropisomers. This protocol is tolerant of various five-membered biaryls containing benzothiophenes and benzofurans, providing pentatomic biaryls with good to excellent enantioselectivities (up to 99% ee).