A novel nanoliposomal formulation of the FDA approved drug Halofantrine causes cell death of Leishmania donovani promastigotes in vitro

Stuti Bhagat, Yashvi Parikh,Sanjay Singh,Souvik Sengupta

Colloids and Surfaces A: Physicochemical and Engineering Aspects（2019）

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摘要

•The FDA approved anti-malarial drug Halofantrine has anti-leishmanial effect.•The novel liposome encapsulated halofantrine (Halolipo) is a stable formulation.•Halolipo decreases cell viability of L. donovani Ag83 promastigotes.•Halolipo causes cellular stress leading to death of L. donovani Ag83. promastigotes.

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关键词

Liposome,Halofantrine,Leishmania,Promastigotes,Cell death

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