Isoproterenol Fails To Activate Cardiac Sk Currents In Mice Heterozygous For The N98s Calmodulin Mutation

Adonis Z. Wu,Wen-Chin Tsai,Dechun Yin,Thomas H. Everett,Zhenhui Chen,Shien-Fong Lin,Peng-Sheng Chen,Michael Rubart-Von Der Lohe

Circulation（2017）

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摘要

Introduction: The human N98S calmodulin (CaM) mutation is associated with catecholaminergic ventricular tachycardia (CPVT). We generated knock-in mice heterozygous for the N98S-CaM mutation in the ...

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关键词

Arrhythmia mapping, Electrophysiology, Gene mutations, Ion channels, Beta-adrenergic receptor agonists

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