Asymmetric Difluoromethylthiolation of Carbon Nucleophiles with Optically Pure Difluoromethylthiolating Reagents Derived from Camphorsultam

*Summary of main observation and conclusion The invention of a family of optically pure electrophilic difluoromethylthiolating reagents 9a-c based on the camphorsultam skeleton was described. These reagents reacted with a variety of soft carbon nucleophiles such as oxazolone, oxindole, benzolactone and beta-ketoester in good to excellent enantioselectivities.