Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: mechanochemical synthesis, characterization, thermal and solubility study

Amanda Cosmo de Almeida,Carolina Torquetti,Patrícia Osório Ferreira,Richard Perosa Fernandes,Everton Carvalho dos Santos,Ana Carolina Kogawa,Flávio Junior Caires

Thermochimica Acta（2020）

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摘要

•New cocrystals of ciprofloxacin were synthesized by the mechanochemical method.•Thermal analysis was fundamental in understanding cocrystal formation.•The solubility of ciprofloxacin increased after cocrystallization.

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关键词

Cocrystal,Ciprofloxacin,Mechanochemical synthesis,Thermal analysis,Solubility study

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