Radiosensitization of high-grade gliomas through induced hyperthermia: Review of clinical experience and the potential role of MR-guided focused ultrasound

•Hyperthermia has been shown to enhance the efficacy of RT in high grade gliomas.•A randomized study showed increased survival if combining hyperthermia and radiation.•Conventional hyperthermia had not been utilized due to the invasive procedure required.•Magnetic resonance focused ultrasound is a new non-invasive method for hyperthermia.•Studies evaluating the efficacy of new hyperthermia methods and radiation are needed.