PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment

•A novel double-barrier nanomaterial (nanoparticles into nanofibers) was formed.•The nanoparticles increased the hydrophilicity of the nanofibers surfaces.•The nanomaterial showed a sustained and continuous release of the model compounds.•The nanoparticles decreased the IC50 against melanoma cells.•The nanoencapsulation increased both skin compound permeation and retention.