microRNA dysregulation in neurodegenerative diseases: A systematic review

Camille A. Juźwik,Sienna S. Drake,Yang Zhang,Nicolas Paradis-Isler, Alexandra Sylvester,Alexandre Amar-Zifkin, Chelsea Douglas,Barbara Morquette,Craig S. Moore,Alyson E. Fournier

Progress in Neurobiology（2019）

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摘要

•Neurodegenerative diseases share many molecular pathways.•miRNAs regulate hubs of gene expression and are dysregulated in many neurodegenerative diseases.•Common pathways targeted by regulated miRNAs revealed potential functional overlap across neurodegenerative diseases.

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关键词

3’ UTR,AD,AMPAR,ALS,AMD,BBB,BDNF,CNS,JNK,DMT,EAE,FICZ,GDNF,HD,IFN,miRNA,IOP,miRISC,MS,DM,NAWM,PD,PRISMA,TCDD

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