A CMOS Electrochemical Biochip With 32 $\times$ 32 Three-Electrode Voltammetry Pixels
IEEE Journal of Solid-State Circuits(2019)
摘要
A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32
$\times $
32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100
$\mu \text{m}\,\times 100\,\,\mu \text{m}$
pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel
$\Sigma \Delta $
current detection circuitry with 280 fA rms input-referred noise (0.1–20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.
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关键词
Biosensors,Electrodes,DNA,Surface impedance,Transducers,Testing,Biological system modeling
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