Efficacy, safety and immunogenicity of a pneumococcal protein-based vaccine co-administered with 13-valent pneumococcal conjugate vaccine against acute otitis media in young children: A phase IIb randomized study.

Laura L Hammitt, James C Campbell,Dorota Borys,Robert C Weatherholtz,Raymond Reid,Novalene Goklish,Lawrence H Moulton,Magali Traskine,Yue Song,Kristien Swinnen,Mathuram Santosham,Katherine L O'Brien

Vaccine（2019）

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摘要

•Protein antigens could offer serotype-independent protection against pneumococcal infection.•dPly/PhtD was assessed in healthy Native American infants when co-administered with PCV13.•Vaccine efficacy against AOM and ALRI was evaluated.•dPly/PhtD was immunogenic but incremental efficacy against AOM over PCV13 was not demonstrated.

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关键词

Streptococcus pneumoniae,Immunogenicity,Reactogenicity,Acute otitis media,Vaccines,Native American

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