Prospective multicentre study using high intensity focused ultrasound (HIFU) for the focal treatment of prostate cancer: Safety outcomes and complications.

•HIFU for the treatment of localized prostate cancer is feasible and safe.•Most adverse effects are well manageable and major complications rare.•The inclusion of the urethra in the ablation zone must be avoided whenever possible.•Tumors treated at the anterior base provoke the highest complication rates.