The effect of increased inoculum on oral rotavirus vaccine take among infants in Dhaka, Bangladesh: A double-blind, parallel group, randomized, controlled trial.

Benjamin Lee,Dorothy M Dickson,Masud Alam,Sajia Afreen,Abdul Kader, Faria Afrin,Tania Ferdousi, Christina F Damon, Soyeon K Gullickson,Monica M McNeal, Daniel M Bak,Mona Tolba,Marya P Carmolli,Mami Taniuchi,Rashidul Haque,Beth D Kirkpatrick

Vaccine（2020）

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摘要

•Oral rotavirus vaccines underperform in low-income countries.•A double vaccine dose did not improve immune response among infants in Bangladesh.•Infants with vaccine replication had improved antibody responses.•Interventions to improve gut health and promote vaccine replication are needed.

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关键词

Rotavirus,Oral vaccine,Vaccine underperformance,Immunogenicity,Vaccine shedding,Vaccine take

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