Revisiting serum β-hCG cut-off levels and pregnancy outcomes using single embryo transfer
Journal of Assisted Reproduction and Genetics(2019)
摘要
Purpose The objective of this study is to identify the pregnancy outcomes based on day-16 β-hCG level assessed with modern assays, in fresh single embryo transfers. Methods A retrospective cohort study at a single academic center between 2013 and 2017. A total of 1076 pregnancies were included. Results Pregnancies were divided into 10% groupings of 107–108 patients each. The 10 groups did not differ for baseline characteristics. There was no difference on outcomes based on cleavage or blastocyst transfer. At a serum β-hCG level of 103 ± 13 (range 74–135), 50% had a biochemical loss. Biochemical pregnancy losses remained 21% at serum β-hCG range (136–197). It was only once serum β-hCG level reached 199–252 that the probability of a biochemical pregnancy loss was 12%. Interestingly, if a clinical pregnancy is present even at low day-16 serum β-hCG levels, the likelihood of live birth is approximately 50%. This maximizes to 75% when the serum β-hCG level was at least 253 IU/L. The relationship between serum day-16 β-hCG levels and clinical pregnancy or live birth is quite strong with correlation coefficients above 0.8 which accounted for more than 75% of the variability in outcomes in both cases. Receiver operator curves determined that the cut-off for a clinical pregnancy was 190 and for live birth, it was 213 IU/L. Conclusion An increase in the serum β-hCG levels at which to expect a reassuring outcome is required based on modern assays, as compared with the old cut-off levels.
更多查看译文
关键词
Beta hCG,Biochemical pregnancy,hCG immunoassay,Pregnancy outcome
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要