Clozapine and cardiotoxicity – A guide for psychiatrists written by cardiologists

•Cardiovascular side-effects of clozapine are rare but include life-threatening myocarditis and dilated cardiomyopathy, but there is no clear evidence that the dose of clozapine has a direct effect on the risk of cardio-toxicity.•Clozapine-induced cardiotoxicity is likely over-reported in the literature with few patients receiving appropriate cardiac investigations.•Only one protocol for monitoring of clozapine-induced cardiotoxicity exists which recommend baseline troponin, C-reactive protein and transthoracic echocardiogram.