Nanocarrier Systems Assembled from PEGylated Hyperbranched Poly(Arylene Oxindole)

Al Halifa Soultan,Dennis Lambrechts,Thomas Verheyen,Hans Van Gorp,Maarten B.J. Roeffaers,Mario Smet,Wim M. De Borggraeve,Jennifer Patterson

European Polymer Journal（2019）

引用 7|浏览32

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摘要

•New amphiphilic hyperbranched poly(arylene oxindole)s by PEGylation using CuAAC.•Spherical nanoparticles with tunable size and zeta potential from PEGylation degree.•Efficient loading and release of compounds interacting with poly(arylene oxindole).•Nanoparticles demonstrate fast cellular uptake with low intercellular variability.•Intracellular accumulation of fluorescent nanoparticles correlates with dose.

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关键词

PEGylation,Hyperbranched polymers,Cisplatin,Drug release,Nanomaterials,Cellular uptake

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