A comparison of the effects of clozapine and its metabolite norclozapine on metabolic dysregulation in rodent models

J.W.Y. Yuen,C. Wu, C.K. Wang,D.D. Kim,R.M. Procyshyn,W.G. Honer,A.M. Barr

Neuropharmacology（2020）

引用 13|浏览6

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摘要

•Clozapine increased fasting glucose levels and caused glucose intolerance.•Norclozapine increased fasting glucose only at the highest dose.•Both drugs caused potent and long-lasting whole body insulin resistance.

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关键词

Clozapine,Glucose tolerance test,Hyperinsulinemic-euglycemic clamp,N-Desmethylclozapine,Norclozapine,Rat

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