S-adenosyl-l-methionine (SAMe), cannabidiol (CBD), and kratom in psychiatric disorders: Clinical and mechanistic considerations

•SAMe is considered effective and safe as a natural treatment for depression.•Cannabidiol has biochemical evidence suggesting benefit in psychiatric disorders.•Kratom may alleviate psychiatric disorders or facilitate opioid discontinuation.•These medications, particularly kratom, may have some serious adverse effects.•These remedies should be used cautiously, preferably under clinician supervision.