Tp53i11 Suppresses Epithelial-Mesenchymal Transition And Metastasis Of Breast Cancer Cells

Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatment upregulated the expression of HIF1 alpha, but reduced TP53I11 protein levels and TP53I11 overexpression reduced HIF1 alpha expression under normal culture and hypoxicconditions, and in xenografts of MDA-MB-231 cells. Considering HIF1 alpha is a master regulator of the hypoxic response and that hypoxia is a crucial trigger of cancer metastasis, our study suggests that TP53I11 may suppress EMT and metastasis by reducing HIF1 alpha protein levels in breast cancer cells.