Semi-elastic core-shell nanoparticles enhanced the oral bioavailability of peptide drugs

We pioneered the semi-elastic core-shell nanoparticles as the carriers of the oral peptide drug and investigate the potential of enhancing the oral bioavailability of peptide drugs. These results in vitro cellular uptake and in vivo pharmacokinetic experiments demonstrated that the semi-elastic core-shell poly(lactic-co-glycolic acid) (PLGA)-lipid nanoparticles (LNPs) would be an excellent oral peptide delivery system for enhancing oral peptide bioavailability and worthy of further investigation as a promising candidate for oral disease treatment.