Hedyosulide, a novel trypanosomicidal sesterterpene lactone from Hedyosmum brasiliense Mart. ex Miq

Cynthia Murakami, Rodrigo Sant’Ana Cabral,Kaio S. Gomes,Thais A. Costa-Silva,Maiara Amaral,Maiara Romanelli,Andre G. Tempone,João Henrique G. Lago,Vanderlan da S. Bolzani,Paulo Roberto H. Moreno,Maria Cláudia M. Young

Phytochemistry Letters（2019）

引用 6|浏览5

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摘要

•Hedyosulide is a new sesterterpene lactone from Hedyosmum brasiliense Mart. ex Miq.•Hedyosulide was highly selective for the most infective forms Trypanosoma cruzi.•Most of the isolated sesquiterpene lactones were not trypanosomicidal.•This sesterterpene lactone can be a model for designing new anti-T. cruzi drugs.

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关键词

Hedyosmum brasiliense,Chloranthaceae,Sesterterpene,Sesquiterpene lactones,Antiprotozoal,Trypanosoma cruzi

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