Multi‐component reaction‐functionalized chitosan complexed with copper nanoparticles: An efficient catalyst toward A 3 coupling and click reactions in water

A novel bio-nanocomposite nanocatalyst with highly dispersed particles is synthesized through covalent functionalization of chitosan biopolymer by the multicomponent reaction (MCR) strategy. Surface functionalization of chitosan through MCR is led to the grafting of carboxamide type ligands with a high affinity toward complexation with copper nanoparticles. The catalytic activity of the synthesized catalyst was explored in various transformations such as A(3) coupling and click reactions in water. Reusability and non-hazardous nature of the catalyst, mild reaction conditions, operational simplicity, high yielding, and using water as a solvent are the main advantages of this catalytic protocol.