“CHOICES”: An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy

•Recognition the etiologies of ATL is important due to its potentially reversible nature after treatment or removal of the toxin.•“CHOICES” is useful to memorize etiologies associated with PVWM injury in non-metabolic and non-infectious ATL patients.•Reduced diffusion is an early and important imaging finding to evaluate patients with non-metabolic and non-infectious ATL patients.