Androgen receptor plasticity and its implications for prostate cancer therapy

Oliver Snow,Nada Lallous,Kriti Singh,Nathan Lack,Paul Rennie,Artem Cherkasov

Cancer Treatment Reviews（2019）

引用 42|浏览54

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摘要

•Androgen receptor is one of the most studied drug targets.•Activating mutations in androgen receptor major cause of resistance.•Splice variants are additionally problematic for prostate cancer resistance.•Plastic nature of androgen receptor makes it especially difficult to target.

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关键词

Cancer resistance,Antiandrogen,Enzalutamide,Prostate cancer,Agonist switch,Androgen receptor

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